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判断健康受精卵的新方法

英国研究人员近日报告说,他们发现一种判断受精卵健康水平的方法。应用这种方法,有可能提高人工授精的成功率。

剑桥大学等机构的研究人员在新一期英国《自然·通信》杂志上报告说,在实验鼠的受精卵内部,细胞质会出现一种类似脉搏的波动。分析显示,波动速度越快的受精卵健康水平越高,未来能够顺利成长的几率也就越大。

人工授精技术目前的成功率只有30%左右,这是因为一些在试管中受精的卵子被植入子宫后没能健康成长,一些接受人工授精的妇女往往要因此经历多轮手术。

目前解决这一问题的方法是同时植入多个受精卵,但这又会造成多胞胎的几率上升。怀上多胞胎的孕妇,更容易出现难产或流产。

领导此次研究的剑桥大学玛格达莱娜教授说,将健康的受精卵植入子宫,对于提高人工授精的成功率来说非常重要。

Oscillations of cytoplasmic speed in fertilized mouse eggs.

英文论文摘要:

Rhythmic actomyosin-driven contractions induced by sperm entry predict mammalian embryo viability

Abstract

Fertilization-induced cytoplasmic flows are a conserved feature of eggs in many species. However, until now the importance of cytoplasmic flows for the development of mammalian embryos has been unknown. Here, by combining a rapid imaging of the freshly fertilized mouse egg with advanced image analysis based on particle image velocimetry, we show that fertilization induces rhythmical cytoplasmic movements that coincide with pulsations of the protrusion forming above the sperm head. We find that these movements are caused by contractions of the actomyosin cytoskeleton triggered by Ca2+oscillations induced by fertilization. Most importantly, the relationship between the movements and the events of egg activation makes it possible to use the movements alone to predict developmental potential of the zygote. In conclusion, this method offers, thus far, the earliest and fastest, non-invasive way to predict the viability of eggs fertilized in vitro and therefore can potentially improve greatly the prospects for IVF treatment.

 

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