当前位置:首页 > 生物研究 > 神经生物学 > 正文

在子宫中追踪胎儿的大脑跨半球连通性

在子宫中追踪胎儿的大脑跨半球连通性

一项新的研究用fMRI(Functional magnetic resonance imaging,功能磁共振成像)来观察和量化不同年龄胎儿的脑部连接发育。许多像自闭症、多动症及诵读困难等脑部疾病被认为是由脑部网络中的沟通中断而造成的。了解大脑网络结构是如何形成的以及何种事件会影响大脑的连通性可帮助研究人员更早地发现异常的大脑发育并研发出针对性的治疗方法。相关研究一封面故事的形式发表在近期出版的《科学-转化医学》(Sci Transl Med)杂志上。

研究人员对一组怀孕24-38周的妇女的胎儿大脑进行了观察。研究所用的是一种叫做功能性MRI或fMRI的技术,这种技术可实时观察脑部不同区域间的沟通信号。通过对40多个脑部区域进行fMRI拍照,研究人员发现,随着胎龄的增加,其右侧脑与左侧脑之间的联系变强。

研究人员还发现,在大脑不同的侧面上,同一部位中的大脑区域,当这些区域之间的距离短的时候,它们之间的联系则更强。而在大脑的较远的、较外边缘的匹配区域之间的联系则较弱。

鉴于已知的儿童大脑网络结构的发育,这种情况是讲得通的。随着孩子年龄的增长,其脑部的连接会跨越更长的距离。这些发现证明,在更长更远的脑部连接被确立之前,胎儿中的脑部连接距离较短。

了解更多:

Cross-Hemispheric Functional Connectivity in the Human Fetal Brain

Sci Transl Med, 20 February 2013 | DOI: 10.1126/scitranslmed.3004978

Compelling evidence indicates that psychiatric and developmental disorders are generally caused by disruptions in the functional connectivity (FC) of brain networks. Events occurring during development, and in particular during fetal life, have been implicated in the genesis of such disorders. However, the developmental timetable for the emergence of neural FC during human fetal life is unknown. We present the results of resting-state functional magnetic resonance imaging performed in 25 healthy human fetuses in the second and third trimesters of pregnancy (24 to 38 weeks of gestation). We report the presence of bilateral fetal brain FC and regional and age-related variation in FC. Significant bilateral connectivity was evident in half of the 42 areas tested, and the strength of FC between homologous cortical brain regions increased with advancing gestational age. We also observed medial to lateral gradients in fetal functional brain connectivity. These findings improve understanding of human fetal central nervous system development and provide a basis for examining the role of insults during fetal life in the subsequent development of disorders in neural FC.

阅读次数:  
更多 相关资讯:
    无相关信息

发表评论