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“DNA砖”的行为类似于微小的乐高积木

纳米级DNA结构

纳米级DNA结构

基于DNA折纸和DNA瓦片,研究人员为了在生物物理、医学及纳米电子学中的可能用途而想出了诱使单股DNA形成各种各样形状的一种方法。 一篇由Kurt Gothelf撰写的《观点栏目》文章对这一发展连同其意义进行了更为详细的解释。

这些由Yonggang Ke及其同事所报告的“DNA砖”会自行组装成复杂、三维的纳米结构,且它们可能对承载及输送某些蛋白质或纳米颗粒是理想的。 

研究人员用每段有32个核苷酸的单股DNA制造了102个微小而独特的形状,其中有些具有复杂的空腔及中空的内部。这些DNA构建块可以至多与4个邻接的DNA股结合,并且,像乐高积木一样,它们中的每一块可被单独地移除或添加。结合DNA折纸,这种制作DNA砖的方法应该为产出更多的甚至更大的纳米结构铺设了道路。











更多了解:Three-Dimensional Structures Self-Assembled from DNA Bricks

We describe a simple and robust method to construct complex three-dimensional (3D) structures by using short synthetic DNA strands that we call “DNA bricks.” In one-step annealing reactions, bricks with hundreds of distinct sequences self-assemble into prescribed 3D shapes. Each 32-nucleotide brick is a modular component; it binds to four local neighbors and can be removed or added independently. Each 8–base pair interaction between bricks defines a voxel with dimensions of 2.5 by 2.5 by 2.7 nanometers, and a master brick collection defines a “molecular canvas” with dimensions of 10 by 10 by 10 voxels. By selecting subsets of bricks from this canvas, we constructed a panel of 102 distinct shapes exhibiting sophisticated surface features, as well as intricate interior cavities and tunnels.



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