当前位置:首页 > 生物研究 > 生化与分子生物学 > 正文

Cell:CRISPR/Cas9论文 TOP10


 

“Cell Press Selections”是由Cell出版社推出的一份推荐文章集合手册,集中介绍某个生命科学研究领域的最新进展及突出成果。最值得一提的是,这些文章均可以免费获取。本期Cell聚焦CRISPR,回顾了该技术在不同领域的突出成果,共包括10篇论文。

 

在过去的两年里,与CRISPR相关的论文超出了650篇,包括通过基因编辑(基因敲除、敲入、抑制、激活)创造具有特定特征或者疾病的动物模型以及在细胞、受精卵中应用CRISPR等。在疾病治疗领域的应用涉及了HIV、疟疾、癌症、肌肉萎缩症等,这些进展都是令人震惊的。

 

以下就是在这期合集中涉及的10篇论文:

 

序号 论文题目
1 Development And Applications Of CRISPR-Cas9 For Genome Engineering
2 To Acquire Or Resist: The Complex Biological Effects Of CRISPR-Cas Systems
3 CRISPR-Cas Systems: Prokaryotes Upgrade To Adaptive Immunity
4 Crystal Structure Of Cas9 In Complex With Guide RNA And Target DNA
5 CRISPR-Mediated Modular RNA-Guided Regulation Of Transcription In Eukaryotes
6 One-Step Generation Of Mice Carrying Reporter And Conditional Alleles By Crispr/Cas-Mediated Genome Engineering
7 Generation Of Gene-Modified Cynomolgus Monkey Via Cas9/RNA-Mediated Gene Targeting In One-Cell Embryos
8 Dynamic Imaging Of Genomic Loci In Living Human Cells By An Optimized CRISPR/Cas System
9 Highly Efficient Targeted Mutagenesis Of Drosophila With The CRISPR/Cas9 System
10 An iCRISPR Platform For Rapid, Multiplexable, And Inducible Genome Editing In Human Pluripotent Stem Cells

 

点击以下链接可免费查看完整十篇论文

 

Insights into the diverse application of CRISPR technology

阅读次数:  

发表评论