Nat Med：肠道细菌与中风的关系

 

肠道菌缓解中风的机制

 

研究人员使用两组小鼠，抗生素处理的小鼠（A组）和未接触抗生素的小鼠（B组），两周后再诱导小鼠发生缺血性中风，B组严重程度显著低于A组，中风损伤小了60%。进一步研究发现，小肠菌群失调能够改变场内免疫稳态，这个过程与调节性T细胞的增加和白介素(IL)17+gd T细胞的减少息息相关。该研究揭示了从未被揭示肠脑轴、肠道菌群及脑膜IL-17+gd T细胞对缺血性损伤影响的知识。

 

参阅文献：

Nat Med. 2016 Mar 28;pii:nm.4068. doi:10.1038/nm.4068. 

Commensal gut bacteria impact the host immune system and can influence disease processes in several organs, including the brain. However, it remains unclear whether the microbiota has an impact on the outcome of acute brain injury. Here we show that antibiotic-induced alterations in the intestinal flora reduce ischemic brain injury in mice, an effect transmissible by fecal transplants. Intestinal dysbiosis alters immune homeostasis in the small intestine, leading to an increase in regulatory T cells and a reduction in interleukin (IL)-17-positive ?? Tcells through altered dendritic cell activity. Dysbiosis suppresses trafficking of effector T cells from the gut to the leptomeninges after stroke. Additionally, IL-10 and IL-17 are required for the neuroprotection afforded by intestinal dysbiosis. The findings reveal a previously unrecognized gut-brain axis and an impact of the intestinal flora and meningeal IL-17(+) ?? T cells on ischemic injury.

阅读次数：