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Cell Metabolism:肠道细菌影响食欲

 最新研究表明肠道微生物可以影响你的食欲。一般在进餐20分钟内,肠道菌中的大肠杆菌E. Coil进入了快速增长期,影响肠-脑信号的释放(如胰高血糖素样肽-1,GLP-1和肽YY,PYY),并激活大脑中的食欲调控神经元。20分钟后,E.coil的生长进入平台期,并改变蛋白表达谱,产生一种“饱涨”蛋白ClpB,该蛋白也可增加神经元放电,降低食欲。

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参阅文献:
Gut Commensal E. coli Proteins Activate Host Satiety Pathways following Nutrient-Induced Bacterial Growth
Cell Metabolism, Volume 23, Issue 2, 9 February 2016, Pages 324–334
The composition of gut microbiota has been associated with host metabolic phenotypes, but it is not known if gut bacteria may influence host appetite. Here we show that regular nutrient provision stabilizes exponential growth of E. coli, with the stationary phase occurring 20 min after nutrient supply accompanied by bacterial proteome changes, suggesting involvement of bacterial proteins in host satiety. Indeed, intestinal infusions of E. coli stationary phase proteins increased plasma PYY and their intraperitoneal injections suppressed acutely food intake and activated c-Fos in hypothalamic POMC neurons, while their repeated administrations reduced meal size. ClpB, a bacterial protein mimetic of α-MSH, was upregulated in the E. coli stationary phase, was detected in plasma proportional to ClpB DNA in feces, and stimulated firing rate of hypothalamic POMC neurons. Thus, these data show that bacterial proteins produced after nutrient-induced E. coli growth may signal meal termination. Furthermore, continuous exposure to E. coli proteins may influence long-term meal pattern.
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